nadA [2017-05-09 15:36:37]

quinolinate synthetase

locus: BSU27850

pI: 5.72

mw: 41.33 kDa

protein length: 368 aa

gene length: 1104 bp

function: NAD biosynthesis

product: quinolinate synthetase

essential: no

ec: 2.5.1.72

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

Gene

Coordinates: 2,845,955 → 2,847,061

The protein

Catalyzed reaction/ biological activity

• Glycerone phosphate iminosuccinate = pyridine-2,3-dicarboxylate 2 H₂O phosphate (according to Swiss-Prot)

Protein family

• Type 3 subfamily (according to Swiss-Prot)

[SW|Cofactors]

• [4 Fe- 4 S] cluster [Pubmed|18959769]

Expression and Regulation

Operons

• genes: [gene|D30D059185DFB828AB0FD07D600DBC3FD0973198|nadB]-[gene|1368734DCC28C618AA173B865784BDDAEA912623|nadC]-[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]
  description: [Pubmed|8444804]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8444804], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|510DE075EA964D22C42DEB171509F6CDA600A402|NadR]: repression, [Pubmed|16199587], in [regulon|510DE075EA964D22C42DEB171509F6CDA600A402|NadR regulon]

  regulation

  • repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]

  additional information

  • An [ncRNA|search|antisense RNA] is predicted for '[protein|search|nadB]' [PubMed|20525796]

Labs working on this gene/protein

• [SW|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]

References

• 18959769,16199587,8444804